PKG Inhibitor - Calbiochem (C15-1303-069)

General description

A more specific, reversible, and substrate competitive inhibitor of protein kinase G (K_i = 86 µM) relative to protein kinase A (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

A specific, reversible, and substrate competitive inhibitor of PKG (K_i = 86 µM) relative to PKA (K_i = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: yes

Target K_i: 86 µM against protein kinase G

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH

Other Notes

Glass, D.B., et al. 1983. Biochem. J.213, 159.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 943.11. Empirical Formula: C₃₈H₇₄N₁₈O₁₀. Quality Level: 100. Assay: ≥. 95% (HPLC). form: lyophilized. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated (hygroscopic). solubility: water: 1 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.