General description
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H2O (Cat. No. 508573).
Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Plasma and glandular kallikreins
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
H-D-Phe-Phe-Arg-chloromethylketone, 2TFA
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 41116113
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 520219-10MG
