Auraptene is a monoterpene coumarin originally found in Citrus species. Auraptene exhibits anti-inflammatory, neuroprotective, anti-parasitic, antihypertensive, anti-diabetic, and chemopreventive activities. Auraptene inhibits growth of species of Leishmania, decreases mean arterial pressure, binds estrogen receptors, inhibits ACAT, and induces phase II metabolizing enzymes. Auraptene also inhibits LPS-induced COX-2 expression, loss of body weight, activation of microglia and astrocytes, and brain inflammation in animal models of cerebral ischemia. Additionally, auraptene activates PPARa, improving high fat diet-induced hyperglycemia and alterations in glucose tolerance. This compound also decreases expression of cyclin D1 and delays tumor formation in animal models of mammary carcinogenesis.
- UPC:
- 41122409
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A8070-500 mg
- CAS:
- 495-02-3
