Biochem/physiol Actions PPTN is a very potent (IC 50 = 1 nM) P2Y14 receptor antagonist that does not interact with any other P2Y receptor at concentrations up to 10 μ:M. PPTN blocks UDP-glucose inhibition of forskolin-induced cAMP
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PPTN is a very potent (IC50 = 1 nM) P2Y14 receptor antagonist that does not interact with any other P2Y receptor at concentrations up to 10 μM. PPTN blocks UDP-glucose inhibition of forskolin-induced cAMP accumulation, and neutrophil chemotaxis towards UDP-glucose gradients with nM potency.
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