InformationPQ 401 PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.In vitroPQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.In vivoPQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.Cell Datacell lines：Concentrations：~50 μMIncubation Time：3 daysPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C18H16ClN3O2 Molecular Weight: 341.79
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P408859-1ml
- CAS:
- 196868-63-0
- Product Size:
- 1ml
