Proadifen hydrochloride (C09-1034-089)

SKF-525A HCl (Proadifen) has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.An inhibitor of NOS1, AChR, cytochrome P-450, and KIR6.1. Specifications and Purity: ≥95%. MDL Number: MFCD00055151. Molecular Formula: C23H31NO2 · HCl. Molecular Weight: 389.96. PubChem CID: 65341. Isomeric SMILES: CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(CC)CC.Cl. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S134395-SCI_c4e15c4186ff7dd1338b77f06301096b.pdf.