Cyclooxygenase metabolism of EPA to produce PGE3 has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. PGA3 is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.
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- UPC:
- 51171957
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 10310-50
- CAS:
- 36614-31-0