Prostaglandin F|2|α|diethyl amide is an analog of PGF|2α|in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Studies have shown that bovine and human corneal tissue convert the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF|2α|-NEt2 are inert to corneal amidase activity, and not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity. Specification: A solution in methyl acetate Molecular Formula: C24H43NO4 Molecular Weight: 409.6
- UPC:
- 12352111
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P394339-1mg
- Product Size:
- 1mg
