PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancerAppearance:SolidIC50& Target:IC50: 1.1 nM (BRD4 BD1), 1.4 nM (BRD4 BD2)In Vitro:PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC 50 of 28 nM. PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 11 nM. PROTAC BRD4 DegBiological Activity:PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer. Specification: 0.98 Molecular Formula: C53H61F2N9O11S2 Molecular Weight: 1102.23
- UPC:
- 51171957
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P659242-1mg
- Product Size:
- 1mg
