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PROTAC CDK12/13 Degrader-1 (C09-1165-542)

Aladdin

Catalog No.
C09-1165-542
Manufacturer No.
P659376-10mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $1,621.08
List Price: $1,801.20

PROTAC CDK12/13 Degrader-1 (7f) is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 has anti-proliferative activity and can be used

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PROTAC CDK12/13 Degrader-1 (7f) is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 has anti-proliferative activity and can be used in breIC50& Target:CDK12 2.2 nM (DC 50 ) CDK13 2.1 nM (DC 50 )In Vitro:PROTAC CDK12/13 Degrader-1 (7f) (0.02-10 μM, 150 h) significantly inhibits the proliferation of MFM223 and MDA-MB-231 cells in a dose-dependent manner. PROTAC CDK12/13 Degrader-1 (7f) (500 nM, 4 h) can significantly degrade CDK12 and CDK13 of MFM223In Vivo:The pharmacokinetic parameters of PROTAC CDK12/13 Degrader-1 (7f) in rats. Parameters oral (20mg/kg) iv (10mg/kg) ip (20mg/kg) iv (2.5mg/kg) t 1/2 (h) - 5.28 10.85 5.8 T max (h) 5.33 0.08 2.17 0.08 C max (ng/mL) 7.73 19892.4 24.79 1498.5 C max (nBiological Activity:PROTAC CDK12/13 Degrader-1 (7f) is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC 50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 has anti-proliferative activity and can be used in bre. Molecular Formula: C45H46N10O6 Molecular Weight: 822.91
UPC:
12352209
Condition:
New
Availability:
8-12 weeks
Weight:
1.09 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
P659376-10mg
Product Size:
10mg


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