PROTAC-O4I2 (C09-1165-502)

PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 ( SF3B1 ). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC 50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.Appearance:SolidIC50& Target:CereblonIn Vitro:PROTAC-O4I2 introduces Thalidomide to ubiquitin E3 ligase cereblon (CRBN), which selectively degrades SF3B1 and inhibits tumor growth in cells. PROTAC-O4I2 degrades and inhibits SF3B1 in K562 cells. PROTAC-O4I2 exhibits anti-proliferation effectsIn Vivo:PROTAC-O4I2 (10 μM) significantly increases survival by interference with the maintenance and proliferation of tumor in a Drosophila intestinal tumor model. MCE has not independently confirmed the accuracy of these methods. They are for reference onlBiological Activity:PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 ( SF3B1 ). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC 50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells. Specification: 0.98 Molecular Formula: C29H29ClN6O5S Molecular Weight: 609.1