General description
Fluorogenic proteasome substrate. Also acts as a substrate for calpain, chymotrypsin, and ingensin.
Specificity
Inhibits serine proteases and cysteine proteases.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Proteasome
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
Suc-Leu-Leu-Val-Tyr-AMC
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Anderson, M., et al. 1999. Exp. Eye Res.69, 129.
Rock, K.L., et al. 1994. Cell 78, 761.
Tsubuki, S., et al. 1993. Biochem. Biophys. Res. Commun.196, 1195.
Sasaki, T., et al. 1984. J. Biol. Chem. 259, 12489.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 763.88. Empirical Formula: C40H53N5O10. Quality Level: 100. Assay: ≥. 98% (HPLC). form: amorphous solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: white. solubility: DMSO: 50 . mg/mL. fluorescence: λ. ex . ~380 . nm, λ. em . ~460 . nm. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51112705
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 539142-5MG
