Protein S from Human Plasma, 100æg

Protein S is a single chain vitamin K-dependent glycoprotein containing glycine and NaCl which is thought to function in both coagulation and complement cascades. It is produced in the liver and has been identified in plasma at a concentration of approximately 22 µg/mL. Homozygous deficiency is represented by a serious thrombotic process in the newborn. Acquired deficiences of Protein S have also been described in patients predisposed to thrombosis. The free Protein S functions as an anticoagulant cofactor protein. In the presence of Protein S, a moderate increase (3-10 fold) in the rate of factor Va and factor VIIIa inactivation by APC is observed in plasma and on the surface of unstimulated. Prepared from human plasma that has been shown to be negative for HBsAg and for antibodies to HIV and HCV. Prepared according to published methods.