PSB-12062 (C005B-313001)

Catalog No.: C005B-313001
Mfr. No.: SML0753-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $701.66

List Price: $779.63

Application PSB-12062 has been used as a P2X4 antagonist to pre-treat macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-treat P2X7-deficient BV-2 cells to elucidate

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Description
Specifications

Application

PSB-12062 has been used as a P2X4 antagonist to pre-treat macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-treat P2X7-deficient BV-2 cells to elucidate the roles of P2X4.

Biochem/physiol Actions

PSB-12062 is a P2X4 receptor antagonist. P2X4 receptors are highly expressed in the central nervous system (CNS), and have been studied as a therapeutic target for neutopathic pain, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. PBS-12062 is a new P2X4-specific antagonist with equal potency against human, rat and mouse receptors (IC₅₀s 1.38, 0.92 and 1.76 μM, respecitively). The compound does not display significant inhibition of human P2X1, P2X2, P2X3 or P2X7 at 10 μM.

UPC:: 51293204
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML0753-25MG
CAS:: 55476-47-6

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