Biochem/physiol Actions PSB-CB5 is a potent and selective GPR18 antagonist that inhibits Δ:9-THC-induced GPR18 β:-arrestin recruitment (IC50 = 279 nM: [THC] = EC50 = 7.5 μ:M) with no potency against human GPR55 (IC50 >:10 μ:M)
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PSB-CB5 is a potent and selective GPR18 antagonist that inhibits Δ9-THC-induced GPR18 β-arrestin recruitment (IC50 = 279 nM; [THC] = EC50 = 7.5 μM) with no potency against human GPR55 (IC50 >10 μM) and little or no affinity toward human CB2 and CB1 (Ki = 4.03 μM & >10 μM, respectively).
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