General description
A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett.19, 6161.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51286505
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 540216-10MG