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ptp1b inhibitor - cas 765317-72-4 - calbiochem

PTP1B INHIBITOR - CAS 765317-72-4 - CALBIOCHEM

Catalog No.
C15-1279-986
Mfr. No.
539741-5MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
5
UOM
MG
Price: $590.59
List Price: $656.21

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC 50 = 4 µM and 8 µM for PTP1B 403 and PTP1B 298 , respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B

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General description

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution format (Cat. No. 539749.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PTP1B403

Product does not compete with ATP.

Reversible: yes

Target IC50: 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Shipping Information:

Dry Ice Surcharge & Ice Pack Shipments: $40

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UPC:
12352200
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
539741-5MG
CAS:
765317-72-4
Temperature Control Device:
Yes

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