General description
PyAOP is an extremely effective coupling reagent that mediates amide bond formation with the efficiency of HATU but without the risk of guanidine formation, making it the reagent of choice for peptide cyclization.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references:
[1] F. Albericio, et al. (1997) Tetrahedron Lett., 38, 4853.
Application
PyAOP can be used as a coupling reagent:
- In the synthesis of N,N′-substituted acylguanidines by solid-phase peptide synthesis.
- To facilitate the formation of peptide bonds during the synthesis of cyclic peptide hybrids.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51381514
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 8512210100
- CAS:
- 156311-83-0
