General description
Pyridoxal 5′-phosphate (PLP), an active form of vitamin B
Application
Pyridoxal 5′-phosphate monohydrate has been used:
- as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
- as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
- as a dietary supplement to study its effects on the lethal phenotype of mutant flies
Biochem/physiol Actions
Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
Other Notes
Coenzymes and Cofactors, vol. 1: Vitamin B6, Pyridoxal Phosphate
- UPC:
- 51191956
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 82870-5G