PZ15227 (C005B-309410)

Catalog No.: C005B-309410
Mfr. No.: SML3180-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $411.62

List Price: $457.36

General description PZ15227 is a proteolysis targeting chimeras (PROTACs) based senolytic agent targeting BCL-XL protein. It is a derivative of ABT-263, a Bcl-2 family protein inhibitor.

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Description
Specifications

General description

PZ15227 is a proteolysis targeting chimeras (PROTACs) based senolytic agent targeting BCL-XL protein. It is a derivative of ABT-263, a Bcl-2 family protein inhibitor. PZ15227 degrades Bcl-xl by recruiting celebron (CRBN) E3 ligase in senescent cells but not in platelets. Comparative to its parent compound, PZ15227 is less toxic to human platelets because of low CRBN expression in platelets.

Biochem/physiol Actions

Bcl-xl specific PROTAC that potently targets Bcl-xl for degradation by cereblon E3 ligase

UPC:: 51282531
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3180-5MG
CAS:: 2143464-25-7

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