Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research.In VitroQ134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoQ134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides Dosage: 4 mg/kg Administration: Orally gavage; twice per day; for 7 days Result: Led to improved Y maze performance.Form:Solid. Specifications and Purity: 99%. Molecular Formula: C22H17F3N4O. Molecular Weight: 410.39.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Q646815-50mg
- CAS:
- 2022949-46-6
- Product Size:
- 50mg
