(R)-(-)-2-Amino-5-phosphonopentanoic acid (C09-1023-881)

D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.A selective antagonist of the NMDA receptor. Specification: 0.98 MDL Number: MFCD00078839 Molecular Formula: C5H12NO5P Molecular Weight: 197.13 PubChem CID: 135342 Isomeric SMILES: C(C[C@H](C(=O)O)N)CP(=O)(O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/R137370-SCI_3b32ba21f6fb64808b4d9559afcb1645.pdf