PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC 50 of 5.8 nM (Gs-cAMP).In VitroPW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment. PW0464 (compound 24), the non-catechol agonist, forms bonds with S198 5.42 and S202 5.46 via its fluorine atom. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specifications and Purity: 97%. Molecular Formula: C19H17F2N3O4. Molecular Weight: 389.35. PubChem CID: 86764103. Isomeric SMILES: CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- R647085-5mg
- CAS:
- 1643462-93-4
- Product Size:
- 5mg
