General description
Ramage Amide AM resin comprises Ramage′s dibenzocycloheptadienelinker [1] attached to aminomethylated polystyrene. Following Fmoc removal, the resin can be acylated under standard conditions and used in Fmoc SPPS. The linker is considerably more acid sensitive than the Rink amide or PAL linkers. This enables peptide amides to be released from the resin with 3% TFA in DCM and thus makes it a useful tool for the synthesis of acid sensitive peptides or protected peptide fragments.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] R. Ramage, et al. (1993) Tetrahedron Lett., 34, 6599.
Analysis Note
Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Quality Level: 200. product line: Novabiochem®. . form: beads. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem®. . application(s): peptide synthesis. functional group: amine. storage temp.: 2-8°C. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 13111000
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8551340001
