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RANK/FC CHIMERA MOUSE RECOMBINANT

Catalog No.
C005B-431840
Mfr. No.
R0775-.1MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
0.1
UOM
MG
Price: $995.43
List Price: $1,106.03

Application RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF- Κ: B and c-jun N-terminal kinase, enhancement of T cell

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Application

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

Biochem/physiol Actions

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

UPC:
51182410
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
R0775-.1MG

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