General description

Reagent-cartridge CRBN-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: carboxylic acid
Compatible substrates: amine

Cartridge contents:

Supported carbodiimide and Oxyma Pure (coupling reagents)
Supported carbonate (acid scavenger)
SCX2 (for purification)
Degrader building block linker reagent

Related Cartridges:
SYNPLE-P002 Reagent-cartridge CRBN-PEG2
SYNPLE-P003 Reagent-cartridge CRBN-PEG3
SYNPLE-P004 Reagent-cartridge CRBN-PEG4
SYNPLE-P005 Reagent-cartridge CRBN-PEG5
SYNPLE-P021 Reagent-cartridge VHL-PEG1
SYNPLE-P022 Reagent-cartridge VHL-PEG2
SYNPLE-P023 Reagent-cartridge VHL-PEG3
SYNPLE-P024 Reagent-cartridge VHL-PEG4
SYNPLE-P025 Reagent-cartridge VHL-PEG5
SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
SYNPLE-P082 Reagent-cartridge VHL-COOH-PEG2
SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4
Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks.

Features and Benefits of Synple Platform
Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
Safety – all chemicals are contained in the system, minimizing the user’s exposure
Set-up reaction in less than 5 minutes
Small footprint
Plug & Play system – simple installation
Reaction temperatures from 25 °C – 80 °C
Cartridges available for many different reactions
Prefilled with all required reagents
RFID chip containing optimized reaction protocol
Other Notes
References
An integrated console for capsule-based, automatedorganic synthesis
Legal Information
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

UPC:

41116107

Condition:

New

Availability:

3-5 Days

Weight:

1.00 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

SYNPLE-P072-1EA

Product Size:

1/EA