General description
Reagent-cartridge VHL-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a von Hippel-Lindau (VHL) recruiting ligand ((S,R,S)-AHPC) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.
Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: von Hippel-Lindau (VHL), (S,R,S)-AHPC
Terminal functional group: carboxylic acid
Compatible substrates: amine
Cartridge contents:
- Supported carbodiimide and Oxyma Pure (coupling reagents)
- Supported carbonate (acid scavenger)
- SCX2 (for purification)
- Degrader building block linker reagent
- SYNPLE-P001 Reagent-cartridge CRBN-PEG1
- SYNPLE-P002 Reagent-cartridge CRBN-PEG2
- SYNPLE-P003 Reagent-cartridge CRBN-PEG3
- SYNPLE-P004 Reagent-cartridge CRBN-PEG4
- SYNPLE-P005 Reagent-cartridge CRBN-PEG5
- SYNPLE-P022 Reagent-cartridge VHL-PEG2
- SYNPLE-P023 Reagent-cartridge VHL-PEG3
- SYNPLE-P024 Reagent-cartridge VHL-PEG4
- SYNPLE-P025 Reagent-cartridge VHL-PEG5
- SYNPLE-P072 Reagent-cartridge CRBN-COOH-PEG2
- SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
- SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
- SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
- SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4
Learn more about protein degradation.
Explore all our Protein Degrader Building Blocks.
Features and Benefits of Synple Platform
- Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
- Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
- Safety – all chemicals are contained in the system, minimizing the user’s exposure
- Set-up reaction in less than 5 minutes
- Small footprint
- Plug & Play system – simple installation
- Reaction temperatures from 25 °C – 80 °C
- Cartridges available for many different reactions
- Prefilled with all required reagents
- RFID chip containing optimized reaction protocol
Other Notes
References
An integrated console for capsule-based, automated organic synthesis
Legal Information
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
- UPC:
- 41116104
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- SYNPLE-P082-1EA
- Product Size:
- 1/EA
