General description
A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and >10000 nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.
Biochem/physiol Actions
Primary Target
Noradrenalin transporter
Target Ki: 1.1, 129 and >10000 nM for rat NET, SERT and DAT respectively
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze 9-20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sacchetti, G., et al. 1999. Br. J. Pharmacol.128, 1332.
Wong, E., et al. 2000. Biol. Psychiatry.47, 818.
Millan, M., et al. 2001. J. Pharmacol. Exp. Ther.298,565.
Owen, J., et al. 2003 Neurosci. Lett.348, 171.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51142546
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5041200001