Recombinant Caveolin-2 Antibody (C09-0740-378)

Rabbit anti Human Caveolin-2 Antibody, Recombinant (R02-2G5), could be used for WB, IHC, ICC, IF and so on.Application:WB: 1/500 - 1/1000IHC: 1/50-1/100ICC/IF: 1/50-1/200Protein FunctionMay act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. Post-translationalPost-translational': "Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin. Specifications and Purity: Recombinant (R02-2G5); Rabbit anti Human Caveolin-2 Antibody; WB, IHC, ICC, IF; Unconjugated.