Rabbit anti Human ERK5 Antibody, Recombinant, could be used for WB, IF, ICC and so on.Application:WB: 1/1000-1/2000IF/ICC: 1/50-1/200Protein FunctionPlays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.Post-translationalDually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent. Specification: ExactAb™, Validated, Recombinant, Lot by Lot
- UPC:
- 41181906
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab102241-100μl
- Product Size:
- 100μl
