Recombinant Human CTGF Protein (C09-1186-157)

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description： Connective Tissue Growth Factor (CTGF), also known as CCN2, is a 36-38 kDa member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. Human CTGF shares 94% amino acid (aa) sequence identity with mouse and rat CTGF. Alternative splicing generates an additional isoform with a 27 aa deletion within the TSP-1 domain. CTGF promotes cell adhesion through interactions with a range of cell surface molecules including heparan sulfate proteoglycans (HSPG), LRPAP, and Integrins alpha M, alpha V beta 3, alpha 6 beta 1, alpha IIb beta 3. It also binds to and regulates signaling through the Wnt receptors LRP6 and Frizzled-8 and the NGF receptors TrkA and NGF R. In addition, CTGF binds directly to BMP-4, TGF-beta 1, TGF-beta 2, and VEGF 165. It blocks BMP-4 and VEGF induced responses but enhances TGF-beta induced responses. Within VEGF complexes, CTGF can be degraded by a variety of proteases, resulting in restoration of angiogenic activity. CTGF promotes fibroblast differentiation from mesenchymal stem cells and their production of type I Collagen and Tenascin C. It promotes chondrocyte proliferation and cartilage matrix synthesis. CTGF is expressed in vascular mural and endothelial cells (EC) during development and promotes pericyte-EC association and angiogenesis. It is expressed in the cerebral cortex and olfactory bulb and plays an important role in nervous system development. Specifications and Purity: Carrier Free, >90% (SDS-PAGE), E.coli, His Tag, 253-349 aa.