Purity:≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description: ER beta/ESR2, a nuclear hormone receptor, exhibits estrogen-binding capabilities comparable to those of ESR1/ER-alpha and, in turn, triggers the expression of reporter genes harboring estrogen response elements (ERE) in an estrogen-dependent fashion. However, it is noteworthy that ER beta/ESR2 lacks intrinsic ligand binding ability and displays either no or minimal ERE binding activity, resulting in the attenuation or loss of ligand-dependent transactivation capacity. This dual nature, where it can bind estrogens but lacks the typical ligand-dependent activation potential, underscores its distinct regulatory role and highlights its contribution to the intricate network of estrogen-mediated signaling pathways. Specifications and Purity: Carrier Free, ≥95%(SDS-PAGE)
- UPC:
- 51181912
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- rp183732-10μg
- Product Size:
- 10μg
