Rabbit anti Human JNK1 Antibody, Recombinant (R08-7H1), could be used for WB and so on.Application:WB: 1/500 - 1/1000ICC/IF: 1/50-1/200 Protein FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.Post-translationalDually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Specification: ExactAb™, Validated, Recombinant, 1.0 mg/mL
- UPC:
- 12352203
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab111518-10μl
- Product Size:
- 10μl
