Rabbit anti Human LEF1 Antibody, Recombinant (R02-3A4), could be used for WB, ICC, IF and so on.Application:WB: 1/500 - 1/1000ICC/IF: 1/50 - 1/200Protein FunctionParticipates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. Specifications and Purity: Recombinant (R02-3A4); Rabbit anti Human LEF1 Antibody; WB, ICC, IF; Unconjugated .
- UPC:
- 12352203
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab112963-100μl
- Product Size:
- 100μl
