REPSOX (C005B-431893)

Catalog No.: C005B-431893
Mfr. No.: R0158-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $1,087.11

List Price: $1,207.90

Application RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β: type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

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Description
Specifications

Application

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Biochem/physiol Actions

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)Ã¢â‚¬Âinduced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.

UPC:: 51182410
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: R0158-25MG
CAS:: 446859-33-2

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