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rho/srf pathway inhibitor, ccg-1423 - cas 285986-88-1 - calbiochem

RHO/SRF PATHWAY INHIBITOR C 1PC X 25MG

Sigma Aldrich

Catalog No.
C15-1227-896
Manufacturer No.
555558-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $469.29
List Price: $521.43

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα 12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment

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General description

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lundquist, M.R., et al. 2014. Cell156, 563..
Evelyn, C.R., et al. 2007. Mol. Cancer Ther.6, 2249.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
12352200
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
555558-25MG

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