Biochem/physiol Actions Riociguat is a soluble guanylate cyclase stimulator in clinical trials for pulmonary hypertension. It increases cGMP production and induces pulmonary vasodilation.
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Riociguat is a soluble guanylate cyclase stimulator in clinical trials for pulmonary hypertension. It increases cGMP production and induces pulmonary vasodilation. It has not effect on phosphodiesterases PDE1-9 and PDE11 when used a concentrations less than 3µM.
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