RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1. Specification: ≥98% Molecular Formula: C8H8Cl2N2S· HCl Molecular Weight: 271.59 PubChem CID: 12526767 Isomeric SMILES: C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/R338914-SCI_b356ee58a793b8f4c0b7ae3eda880558.pdf
- UPC:
- 51293010
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- R338914-50mg
- CAS:
- 72214-67-6
- Product Size:
- 50mg
- Hazard Statement Codes:
- H335,H319,H315,H302
- Precautionary Statement Codes:
- P501,P403+P233,P405,P362+P364,P305+P351+P338,P304+P340,P302+P352,P301+P312,P330,P280,P271,P270,P264,P261
