S-23 (C09-1169-594)

S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated ratsIn VitroS-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoBy administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague Dawley rats (in castrated male rats) Dosage: 0.01-3 mg Administration: S.c.; daily for 14 d Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.Form:SolidIC50& Target:Ki: 1.7 nM (Androgen receptor). Specifications and Purity: 99%. Molecular Formula: C18H13ClF4N2O3. Molecular Weight: 416.75. PubChem CID: 24892822. Isomeric SMILES: C[C@](COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O.