S 3304 (C09-1170-383)

S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9 .In VitroS 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:MMP-9. Specification: 0.99 Molecular Formula: C24H20N2O4S2 Molecular Weight: 464.6 PubChem CID: 10718956 Isomeric SMILES: CC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)O