S-(5′-Adenosyl)-L-homocysteine (C09-1034-517)

SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.application：SAH is suitable for use:to investigate whether AdoHcy competes with AdoMet in the down-regulation of reporter activity of LUC reporter geneas a reagent to study the abundance patterns of SAH and its correlation with vertebrate metamorphosisin the optimization of the protein (lysine K) methyltransferase SET7/9 activity assayin the fluorescence polarization (FP) assay during dengue virus methyltransferase activity measurementas a standard for the measurement of SAH from blood samples by high performance liquid chromatography (HPLC) with fluorimetric detection method. Specification: ≥98% MDL Number: MFCD00037388 Molecular Formula: C14H20N6O5S Molecular Weight: 384.41 EC Number: 213-560-8 PubChem CID: 439155 Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N Beilstein Registry Number: 99188 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S139501-SCI_3ce2f4dd00736c73451fcc4804731dd6.pdf