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S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE HUMAN RECOMBINANT EXPRESSED IN E. COLI

Catalog No.
C005B-454624
Mfr. No.
M1949-50UG
Mfr. Name
Sigma-Aldrich
Qty/UOM
1
UOM
EA
Price: $1,390.23
List Price: $1,544.70

Application S-methyl-5′:-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of

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Application

S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .

Biochem/physiol Actions

MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation .

Physical properties

N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Shipping Information:

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UPC:
51111909
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
M1949-50UG
Temperature Control Device:
Yes

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