General description
An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P4) antagonist (IC50 = 25 nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC50 = 6.4 µM, 3.9 µM, 5.5 µM, and 25 µM for S1P1, S1P2, S1P5, and S1P3 (95% inhibition), respectively).
Packaging
Packaged under inert gas
Warning
Toxicity: Regulatory Review (Z)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Guerrero, M., et al. 2011. Bioorg. Med. Chem. Lett.21, 3632.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 389.28. Empirical Formula: C20H18Cl2N2O2. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: white. solubility: DMSO: 100 . mg/mL, clear, colorless. shipped in: ambient. storage temp.: 2-8°C. SMILES string: CC1: CC(: CC(: C1NC(: O)C2: CC: C(O2)C3: C(C: CC(: C3)Cl)Cl)C)CN. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3.- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 567737-5MG