Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) Both forms of sphinganine inhibit PKC by binding at the regulatory phorbol-binding domain (IC50s = 7 and 24 µM for erythro-sphinganine and safingol, respectively). Safingol also inhibits sphingosine kinases (Ki = 3-5 µM). Safingol, alone or in combination with chemotherapeutic agents, is cytotoxic against cancer cell lines.
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- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 18624-5
- Model Number:
- C815R12
- Temperature Control Device:
- Yes
