Sanguinarine chloride hydrate (C09-1031-009)

Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2. Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor. Specification: ≥97% (HPLC) MDL Number: MFCD00012126 Molecular Formula: C20H14ClNO4 · xH2O Molecular Weight: 367.78(anhydrous basis) PubChem CID: 68635 Isomeric SMILES: C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S101540-SCI_90beaaf073a01a8f12f07f7666df4a46.pdf