Application
Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.
Biochem/physiol Actions
SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells.
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
- UPC:
- 51111756
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- S4572-25MG
- CAS:
- 304909-07-7