SANTACRUZAMATE A (C005B-309403)

Catalog No.: C005B-309403
Mfr. No.: SML3184-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $586.61

List Price: $651.79

Biochem/physiol Actions Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = >: 1 μ:M and 433.5 nM, respectively).

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Description
Specifications

Biochem/physiol Actions

Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.).

UPC:: 51171648
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3184-25MG
CAS:: 1477949-42-0

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