SB 202190 (C007B-263464)

SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. The compound inhibits the isoforms p38α and p38β. SB 202190 has displayed the ability to activate CPP32-like caspases and induce apoptosis. Research demonstrates that when one residue of ERK2, a related p38 not inhibited by pyridinyl imidazoles, is changed it allows SB 202190 to bind. Studies have revealed that SB 202190 can improve leukemia cell growth by activating MEK/MAPK, as well as phosphorylate and activate MLK3.An inhibitor of the isoforms p38α and p38β. Specification: 0.99 MDL Number: MFCD00941964 Molecular Formula: C20H14FN3O Molecular Weight: 331.34 PubChem CID: 5169 Isomeric SMILES: C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S134307-SCI_c6279733497728847afe4b2a9a6643c9.pdf