SB-204990 (C005B-310042)

Catalog No.: C005B-310042
Mfr. No.: SML2829-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $914.97

List Price: $1,016.63

Biochem/physiol Actions SB-204990 is a cell-permeable and orally available γ:-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (K i =1 μ:M against human and rat ACL) in a predominantly

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Description
Specifications

Biochem/physiol Actions

SB-204990 is a cell-permeable and orally available γ-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (K_i =1 μM against human and rat ACL) in a predominantly competitive manner with a small but significant uncompetitive component. SB-204990 treatment is shown to suppress the rate of cellular cholesterol and fatty acid synthesis in HepG2 cultures (by 91% & 82%, respectively, with 30 μM SB-204990), and display hypocholesterolaemic and hypolipidaemic efficacy in vivo when administered in the diet (0.05-0.25%, w/w; mice, rats, dogs).

UPC:: 51322400
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2829-25MG
CAS:: 154566-12-8

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