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SB-207266-5 mg

Catalog No.
C08-0325-956
Manufacturer No.
18778-5
Manufacturer Name
Cayman Chemical Company
Quantity
1
Unit of Measure
EA
Price: $220.90
List Price: $245.45

The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.

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The indole derivative SB-207266 is a selective and potent antagonist of the serotonin (5-HT) receptor 5-HT4 with a pA2 value of 10.6 ± 0.1. In COS7 cells, 100 nM SB-207266 inhibited 5-HT4 responses to 5-HT and reduced basal agonist-independent cAMP production. In several animal models, low concentrations of SB-207266 blocked exogenous 5-HT-mediated sensitization of intestinal peristalsis. In a dog model, SB-207266 (0.1–100 pg/kg) dose-dependently reduced responses to 5-HT, with an ID50 value of 1.3 pg/kg. SB-206226 (0.5 mg/kg/24 h) improved cardiac function in a rat model of congestive heart failure.
UPC:
12350000
Condition:
New
Availability:
3 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
18778-5


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